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Is Silver the New Gold? A Systematic Review of the Preclinical Evidence of Its Use in Bone Substitutes as Antiseptic

Authors :
Michele Fiore
Alessandro Bruschi
Claudio Giannini
Lorenzo Morante
Claudia Rondinella
Matteo Filippini
Andrea Sambri
Massimiliano De Paolis
Source :
Antibiotics, Vol 11, Iss 8, p 995 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Antibiotic-laden bone substitutes represent a viable option in the treatment of bone and joint infections with bone defects. In particular, the addition of silver ions or silver nanoparticles to bone substitutes to achieve local antiseptic activity could represent a further contribution, also helping to prevent bacterial resistance to antibiotics. An in-depth search of the main scientific databases was performed regarding the use of silver compounds for bone substitution. The available evidence is still limited to the preclinical level: 22 laboratory studies, 2 animal models, and 3 studies, with both in vitro and in vivo analysis, were found on the topic. Numerous biomaterials have been evaluated. In vitro studies confirmed that silver in bone substitutes retains the antibacterial activity already demonstrated in coatings materials. Cytotoxicity was generally found to be low and only related to silver concentrations higher than those sufficient to achieve antibacterial activity. Instead, there are only a few in vivo studies, which appear to confirm antibacterial efficacy, although there is insufficient evidence on the pharmacokinetics and safety profile of the compounds investigated. In conclusion, research on bone substitutes doped with silver is in its early stages, but the preliminary findings seem promising.

Details

Language :
English
ISSN :
20796382
Volume :
11
Issue :
8
Database :
Directory of Open Access Journals
Journal :
Antibiotics
Publication Type :
Academic Journal
Accession number :
edsdoj.3ee6e07ec754de6929efc65e475a6d5
Document Type :
article
Full Text :
https://doi.org/10.3390/antibiotics11080995