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Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction
- Source :
- Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
- Publication Year :
- 2018
- Publisher :
- Nature Portfolio, 2018.
-
Abstract
- Direct visualization of microglia-mediated synapse pruning has been lacking. This study shows direct evidence of microglia-synapse interaction where microglia do not necessarily ‘eat’ post-synaptic structure but ‘nibble’ on pre-synaptic terminals, much akin to trogocytosis by lymphocytes.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 9
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.3ebaa88953d7458785bcccb29c6b1bc7
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-018-03566-5