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Association between Cesarean section delivery and increased risk of childhood Kawasaki disease

Authors :
Chih-Fu Wei
Mei-Huei Chen
Ching-Chun Lin
Meng-Shan Tsai
Yueliang Leon Guo
Shio-Jean Lin
Mei-Hwan Wu
Wu-Shiun Hsieh
Pau-Chung Chen
Source :
Journal of the Formosan Medical Association, Vol 123, Iss 8, Pp 843-848 (2024)
Publication Year :
2024
Publisher :
Elsevier, 2024.

Abstract

Aim: Cesarean section delivery is associated with microbiota disruption and immuno-dysregulation during childhood, but the association with Kawasaki disease remains uncertain. We aimed to evaluate the association between Cesarean section and Kawasaki disease. Methods: We examined the association between Kawasaki disease between six and eighteen months and Cesarean section within a birth cohort of 15,796 mother-infant pairs in Taiwan. The associations were assessed with Poisson regression in the study population, in the 1:2 propensity score-matched subpopulation, and compared with febrile convulsion, trauma and accidents during the same interval as negative control outcomes. Results: Cesarean section was found to increase the risk of Kawasaki disease among overall population (adjusted relative risk [aRR]: 2.22, 95 % confidence interval (CI): 1.14–4.34) and the matched subpopulation (aRR: 2.29, 95 % CI: 1.14–4.68 in PS-matched subpopulation). Meanwhile, there was no association between Cesarean section and the clinic visits for febrile convulsion, trauma and accidents. Conclusion: In conclusion, this study identified a potential association between Cesarean section delivery and a higher risk of Kawasaki disease during six-to eighteen months of the prospective birth cohort in Taiwan.

Details

Language :
English
ISSN :
09296646
Volume :
123
Issue :
8
Database :
Directory of Open Access Journals
Journal :
Journal of the Formosan Medical Association
Publication Type :
Academic Journal
Accession number :
edsdoj.3e9fdf63abdf496bbe6f1f6298d4574b
Document Type :
article
Full Text :
https://doi.org/10.1016/j.jfma.2023.12.006