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Incorporation of MMP inhibitors into dental adhesive systems and bond strength of coronal composite restorations: A systematic review and meta-analysis of in vitro studies

Authors :
Rayan B. Yaghmoor
Hasan Jamal
Hassan Abed
Elaine Allan
Paul Ashley
Anne Young
Source :
Japanese Dental Science Review, Vol 58, Iss , Pp 298-315 (2022)
Publication Year :
2022
Publisher :
Elsevier, 2022.

Abstract

Purpose: To systematically review in vitro studies that incorporated MMP inhibitors into adhesive systems in terms of the effect on immediate and aged bond strength of dental composite to dentine. Materials and methods: Independently, two reviewers conducted an electronic search in three databases (MEDLINE, EMBASE, and Google Scholar) following the Preferred Reporting Items for Systematic Review and Meta-Analyses Protocols (PRISMA-P), up to 6 March 2022. Results: The search resulted in 894 papers, 33 of which were eligible to be included in the review; of those, 13 fulfilled the meta-analysis eligibility criteria. Nineteen inhibitors were used among the studies, and those included in the meta-analysis were 2%, 0.2% chlorhexidine (CHX), 5 µM GM1489, and 0.5%, 1% benzalkonium chloride (BAC). In the meta-analysis, while above inhibitors showed no adverse effect on bond strength, 0.2% CHX and 5 µM GM1489 caused a significant increase in immediate and 12-months bond strength. All other inhibitors resulted in a significant increase in bond strength at six months of ageing. Conclusions: Incorporation of MMP inhibitors into the adhesive system has no unfavourable effect on immediate bond strength but a favourable effect on longer-term bond strength. Additionally, inhibitors other than CHX could have similar or better effects on bond strength.

Details

Language :
English
ISSN :
18827616
Volume :
58
Issue :
298-315
Database :
Directory of Open Access Journals
Journal :
Japanese Dental Science Review
Publication Type :
Academic Journal
Accession number :
edsdoj.3e9226a8a8114a38b0e26b56689475c9
Document Type :
article
Full Text :
https://doi.org/10.1016/j.jdsr.2022.09.004