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Bioactive Metabolites from Mangrove Endophytic Fungus Aspergillus sp. 16-5B

Authors :
Yayue Liu
Senhua Chen
Zhaoming Liu
Yongjun Lu
Guoping Xia
Hongju Liu
Lei He
Zhigang She
Source :
Marine Drugs, Vol 13, Iss 5, Pp 3091-3102 (2015)
Publication Year :
2015
Publisher :
MDPI AG, 2015.

Abstract

Chemical investigation of the endophytic fungus Aspergillus sp. 16-5B cultured on Czapek’s medium led to the isolation of four new metabolites, aspergifuranone (1), isocoumarin derivatives (±) 2 and (±) 3, and (R)-3-demethylpurpurester A (4), together with the known purpurester B (5) and pestaphthalides A (6). Their structures were determined by analysis of 1D and 2D NMR spectroscopic data. The absolute configuration of Compound 1 was determined by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra, and that of Compound 4 was revealed by comparing its optical rotation data and CD with those of the literature. The structure of Compound 6 was further confirmed by single-crystal X-ray diffraction experiment using CuKα radiation. All isolated compounds were evaluated for their α-glucosidase inhibitory activities, and Compound 1 showed significant inhibitory activity with IC50 value of 9.05 ± 0.60 μM. Kinetic analysis showed that Compound 1 was a noncompetitive inhibitor of α-glucosidase. Compounds 2 and 6 exhibited moderate inhibitory activities.

Details

Language :
English
ISSN :
16603397
Volume :
13
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Marine Drugs
Publication Type :
Academic Journal
Accession number :
edsdoj.3e77edc8c248ddaad9522c38e17e25
Document Type :
article
Full Text :
https://doi.org/10.3390/md13053091