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Vascular Risk Factors and Biomarkers of Endothelial Dysfunction in Chronic Migraine patients- A Cross-sectional Study

Authors :
Hari Nath Yadav
Sanjay Rao Kordcal
Manju Yadav
Bhawna Mahajan
Ashish Kumar Duggal
Poonam Narang
Meenakshi Thakkar
Debashish Chowdhury
Source :
Journal of Clinical and Diagnostic Research, Vol 17, Iss 09, Pp 28-32 (2023)
Publication Year :
2023
Publisher :
JCDR Research and Publications Private Limited, 2023.

Abstract

Introduction: The available literature on vascular risk and endothelial dysfunction in patients with Chronic Migraine (CM) is limited. CM patients are known to have a higher risk of cardiovascular and cerebrovascular events. The present study aims to characterise the vascular risk and endothelial dysfunctions in CM patients and compare them with Healthy Controls (HC). Aim: To assess the vascular risk factors and biomarkers of endothelial dysfunction in CM patients and compare them with healthy non-headache controls. Materials and Methods: This cross-sectional study was conducted from October 2021 to January 2023 at the headache clinic of GB Pant Institute of Postgraduate Medical Education and Research in Delhi, India. The patients were diagnosed with CM using the International Classification of Headache Disorders-3 (ICHD-3) criteria. The patients were drug-naïve for preventive medications and did not have medication overuse headache. Clinical vascular risk factors such as Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Ankle Brachial Index (ABI), Body Mass Index (BMI), and Waist Hip Ratio (WHR) were measured. A battery of biochemical vascular risk factors, including serum C-reactive protein, leptin, insulin, fasting and post-prandial glucose, Glycosylated Haemoglobin (HbA1c), lipid profile, lipoprotein-A, pro-Brain Natriuretic Peptide (proBNP), and serum biomarkers of endothelial dysfunction like Intercellular Adhesion Molecules-1 (ICAM-1), Myeloperoxidase (MPO), Interleukin-6 (IL-6), Tumour Necrosis Factor-Alpha (TNFalpha), Asymmetric Dimethyl Arginine (ADMA), fibrinogen, and von Willebrand’s factor were measured in all patients during the interictal period. Statistical analysis was done using the Statistical Package for Social Sciences (SPSS) version 25.0, and the Mann-Whitney U test, student’s t-test, and Chi-square tests were applied. Results: Thirty-two patients with CM and thirty-two nonheadache healthy subjects were included in the study (age 30.6±8.8 years; 29 females and 3 males) vs. (31.7±7.9 years; 19 females and 13 males, respectively). Compared to HC, CM patients had significantly higher DBP (81.0±8.0 mmHg vs. 66.2±6.2 mmHg; p

Details

Language :
English
ISSN :
2249782X and 0973709X
Volume :
17
Issue :
09
Database :
Directory of Open Access Journals
Journal :
Journal of Clinical and Diagnostic Research
Publication Type :
Academic Journal
Accession number :
edsdoj.3e5b75422414381a89f0483deaba782
Document Type :
article
Full Text :
https://doi.org/10.7860/JCDR/2023/64173.18431