The transcription factor Foxp1 preserves integrity of an active Foxp3 locus in extrathymic Treg cells

Authors :: Sayantani Ghosh
Sinchita Roy-Chowdhuri
Keunsoo Kang
Sin-Hyeog Im
Dipayan Rudra
Source :: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Publication Year :: 2018
Publisher :: Nature Portfolio, 2018.
Abstract: Regulatory T (Treg) cells suppress immune cell activation to maintain immune homeostasis, and have their lineage enforced by the master transcription factor Foxp3. Here the authors show that Foxp3 expression is promoted and maintained by a related family member, Foxp1, specifically in peripherally induced Treg but not in Treg cells of thymic origin.

Full Text Access

Tools