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Brugada-Phenocopy Induced by Propafenone Overdose and Successful Treatment: A Case Report

Authors :
Mehmet Emre Arı
Filiz Ekici
Source :
Balkan Medical Journal, Vol 34, Iss 5, Pp 473-475 (2017)
Publication Year :
2017
Publisher :
Galenos Publishing House, 2017.

Abstract

Background: Brugada syndrome is an inherited arrhythmogenic disease that may cause sudden cardiac death due to ventricular fibrillation in young adults. Brugada syndrome caused by propafenone intoxication has been noted rarely in the literature. We report a rare case, Brugada phenocopy due to propafenone intoxication and its treatment. Case Report: A 15-year-old girl having a seizure was brought to the emergency room. She took 1.5 g propafenone (Rythmol, Abbott, Chicago, IL, USA) for suicidal intention. She had metabolic acidosis. Long QRS interval and ST elevation in leads V1 through V3 were seen on electrocardiography. After bicarbonate infusion for 4 hours, haemodynamic and neurologic findings were recovered, and all electrocardiography abnormalities disappeared. The Brugada-like electrocardiography pattern was not recognized in her surface and 24-hour Holter electrocardiography at follow-up. Ajmaline challenge test was negative 2 weeks later. Conclusion: Absence of symptoms and documented ventricular tachycardia, negative challenge test, and a negative family history demonstrated that the Brugada phenocopy was a transient finding in this case and related to propafenone intoxication

Details

Language :
English
ISSN :
21463123 and 21463131
Volume :
34
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Balkan Medical Journal
Publication Type :
Academic Journal
Accession number :
edsdoj.3e1b0adc981841d383508c7a83523ef3
Document Type :
article
Full Text :
https://doi.org/10.4274/balkanmedj.2016.1185