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Characterization of Physicians That Might Be Reluctant to Propose HIV Cure-Related Clinical Trials with Treatment Interruption to Their Patients? The ANRS-APSEC Study

Authors :
Christel Protiere
Lisa Fressard
Marion Mora
Laurence Meyer
Marie Préau
Marie Suzan-Monti
Jean-Daniel Lelièvre
Olivier Lambotte
Bruno Spire
the APSEC Study Group
Source :
Vaccines, Vol 8, Iss 2, p 334 (2020)
Publication Year :
2020
Publisher :
MDPI AG, 2020.

Abstract

HIV cure-related clinical trials (HCRCT) with analytical antiretroviral treatment interruptions (ATIs) have become unavoidable. However, the limited benefits for participants and the risk of HIV transmission during ATI might negatively impact physicians’ motivations to propose HCRCT to patients. Between October 2016 and March 2017, 164 French HIV physicians were asked about their level of agreement with four viewpoints regarding HCRCT. A reluctance score was derived from their answers and factors associated with reluctance identified. Results showed the highest reluctance to propose HCRCT was among physicians with a less research-orientated professional activity, those not informing themselves about cure trials through scientific literature, and those who participated in trials because their department head asked them. Physicians’ perceptions of the impact of HIV on their patients’ lives were also associated with their motivation to propose HCRCT: those who considered that living with HIV means living with a secret were more motivated, while those worrying about the negative impact on person living with HIV’s professional lives were more reluctant. Our study highlighted the need to design a HCRCT that minimizes constraints for participants and for continuous training programs to help physicians keep up-to-date with recent advances in HIV cure research.

Details

Language :
English
ISSN :
2076393X
Volume :
8
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Vaccines
Publication Type :
Academic Journal
Accession number :
edsdoj.3dee0946145d41548fee165e0ea9c2b2
Document Type :
article
Full Text :
https://doi.org/10.3390/vaccines8020334