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Characterization of a Lipoyl Domain-Independent B-Cell Autoepitope on the Human Branched-Chain Acyltransferase in Primary Biliary Cirrhosis and Overlap Syndrome with Autoimmune Hepatitis
- Source :
- Clinical and Developmental Immunology, Vol 10, Iss 2-4, Pp 173-181 (2003)
- Publication Year :
- 2003
- Publisher :
- Wiley, 2003.
-
Abstract
- Background and aims: Antimitochondrial antibodies (AMA) which recognize pyruvate acetyltransferase (PDC-E2) represent a highly diagnostic feature of primary biliary cirrhosis (PBC). The analysis of immunofluorescence (IF)-AMA-positive sera in PBC patients indicates a conformational epitope located within the lipoyl binding domain of bovine branched-chain acyltransferase (BCKADC-E2) alone or in combination with AMA directed against PDC-E2 the significance of which is presently unclear. In the present study, immunoreactivities and disease associations of AMA against BCKADC-E2 were analyzed. B-cell autoepitopes on BCKADC-E2 were mapped by immunoprecipitation assay.
- Subjects :
- Immunologic diseases. Allergy
RC581-607
Subjects
Details
- Language :
- English
- ISSN :
- 17402522 and 17402530
- Volume :
- 10
- Issue :
- 2-4
- Database :
- Directory of Open Access Journals
- Journal :
- Clinical and Developmental Immunology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.3de24ab0d8cb4a749d2344a85b48a8fb
- Document Type :
- article
- Full Text :
- https://doi.org/10.1080/10446670310001642159