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Rationally Designed Oral DOX Gels for Colon-Specific Administration

Authors :
Jie Li
Luping Ma
Cheng Wang
Pengju Jiang
Pengfei Cui
Jianhao Wang
Source :
Gels, Vol 8, Iss 12, p 759 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Colorectal cancer (CRC) is the third leading cause of death from cancer in both men and women. Traditional CRC dosage forms deliver the drug to both desired and unwanted sites of drug action, resulting in a number of negative side effects. Chemotherapeutic and chemopreventive agents are being targeted and delivered directly to the colon and rectum using targeted oral drug delivery systems. The main challenge in successfully targeting drugs to the colon via the oral route is avoiding drug absorption/degradation in the stomach and small intestine before the dosage form reaches the colon. In this study, we employed biocompatible chalk to adsorb DOX, then mixed pectin and cross-linked with calcium ions to form PC–DOX gels. The presence of cross-linked pectin and chalk can provide dual protection for the drug, significantly reducing drug leakage in gastric acid. In vitro release results showed that the designed PC–DOX could achieve 68% colon delivery efficiency. In the simulated colon environment, the released semi-degradable chalk did not affect the uptake of doxorubicin by colon cancer cells. Finally, in vivo simulation experiments in mice showed that rationally designed PC–DOX could achieve the highest colonic delivery efficiency. Our strategy has great potential for application in the treatment of colon cancer.

Details

Language :
English
ISSN :
23102861 and 87472481
Volume :
8
Issue :
12
Database :
Directory of Open Access Journals
Journal :
Gels
Publication Type :
Academic Journal
Accession number :
edsdoj.3dbd84e55d8747248153ff86af32555e
Document Type :
article
Full Text :
https://doi.org/10.3390/gels8120759