Increased expression of pregnancy up-regulated non-ubiquitous calmodulin kinase is associated with poor prognosis in clear cell renal cell carcinoma.

Authors :: Song Wu
Zhaojie Lv
Yong Wang
Liang Sun
Zhimao Jiang
Congjie Xu
Jun Zhao
Xiaojuan Sun
Xianxin Li
Lijun Hu
Aifa Tang
Yaoting Gui
Fangjian Zhou
Zhiming Cai
Rongfu Wang
Source :: PLoS ONE, Vol 8, Iss 4, p e59936 (2013)
Publication Year :: 2013
Publisher :: Public Library of Science (PLoS), 2013.
Abstract: PURPOSE: The aims of this study were to evaluate the clinical significance and potential prognostic value of pregnancy up-regulated non-ubiquitous calmodulin kinase (PNCK) in clear cell renal cell carcinoma (ccRCC) patients. MATERIALS AND METHODS: The expression of PNCK mRNA was determined in 24 paired samples of ccRCCs and adjacent normal tissues using real-time RT-PCR. The expression of PNCK was determined in 248 samples of ccRCCs and 92 paired samples of adjacent normal tissues by immunohistochemical analysis. Statistical analysis was performed to define the relationship between PNCK expression and the clinical features of ccRCC. RESULTS: The mRNA level of PNCK was significantly higher in tumorous tissues than in the adjacent non-tumorous tissues (p

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