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Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes

Authors :
Viktoria Gusarova
Colm O’Dushlaine
Tanya M. Teslovich
Peter N. Benotti
Tooraj Mirshahi
Omri Gottesman
Cristopher V. Van Hout
Michael F. Murray
Anubha Mahajan
Jonas B. Nielsen
Lars Fritsche
Anders Berg Wulff
Daniel F. Gudbjartsson
Marketa Sjögren
Connor A. Emdin
Robert A. Scott
Wen-Jane Lee
Aeron Small
Lydia C. Kwee
Om Prakash Dwivedi
Rashmi B. Prasad
Shannon Bruse
Alexander E. Lopez
John Penn
Anthony Marcketta
Joseph B. Leader
Christopher D. Still
H. Lester Kirchner
Uyenlinh L. Mirshahi
Amr H. Wardeh
Cassandra M. Hartle
Lukas Habegger
Samantha N. Fetterolf
Teresa Tusie-Luna
Andrew P. Morris
Hilma Holm
Valgerdur Steinthorsdottir
Patrick Sulem
Unnur Thorsteinsdottir
Jerome I. Rotter
Lee-Ming Chuang
Scott Damrauer
David Birtwell
Chad M. Brummett
Amit V. Khera
Pradeep Natarajan
Marju Orho-Melander
Jason Flannick
Luca A. Lotta
Cristen J. Willer
Oddgeir L. Holmen
Marylyn D. Ritchie
David H. Ledbetter
Andrew J. Murphy
Ingrid B. Borecki
Jeffrey G. Reid
John D. Overton
Ola Hansson
Leif Groop
Svati H. Shah
William E. Kraus
Daniel J. Rader
Yii-Der I. Chen
Kristian Hveem
Nicholas J. Wareham
Sekar Kathiresan
Olle Melander
Kari Stefansson
Børge G. Nordestgaard
Anne Tybjærg-Hansen
Goncalo R. Abecasis
David Altshuler
Jose C. Florez
Michael Boehnke
Mark I. McCarthy
George D. Yancopoulos
David J. Carey
Alan R. Shuldiner
Aris Baras
Frederick E. Dewey
Jesper Gromada
Source :
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Publication Year :
2018
Publisher :
Nature Portfolio, 2018.

Abstract

Genetic variation in ANGPTL4 is associated with lipid traits. Here, the authors find that predicted loss-of-function variants in ANGPTL4 are associated with glucose homeostasis and reduced risk of type 2 diabetes and that Angptl4 −/− mice on a high-fat diet show improved insulin sensitivity.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
9
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.3d832a109514250b3a42f9eaa1a1b95
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-04611-z