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Allogeneic unrelated bone marrow transplantation from older donors results in worse prognosis in recipients with aplastic anemia

Authors :
Yasuyuki Arai
Tadakazu Kondo
Hirohito Yamazaki
Katsuto Takenaka
Junichi Sugita
Takeshi Kobayashi
Yukiyasu Ozawa
Naoyuki Uchida
Koji Iwato
Naoki Kobayashi
Yoshiyuki Takahashi
Ken Ishiyama
Takahiro Fukuda
Tatsuo Ichinohe
Yoshiko Atsuta
Takehiko Mori
Takanori Teshima
Source :
Haematologica, Vol 101, Iss 5 (2016)
Publication Year :
2016
Publisher :
Ferrata Storti Foundation, 2016.

Abstract

Allogeneic bone marrow transplantation is an essential therapy for acquired aplastic anemia and prognosis has recently improved. However, engraftment failure and graft-versus-host disease are potential fatal complications. Various risk factors for poor prognosis have been identified, such as patient age and human-leukocyte antigen disparity, but the relationship between donor age and prognosis is still unknown. Therefore, we performed a cohort study to compare the prognosis of unrelated bone marrow transplantation from younger and older donors using the registry database in Japan. We evaluated 427 patients (age 16–72 years) with aplastic anemia who underwent bone marrow transplantation from younger (≤39 years, n=281) or older (≥40 years, n=146) unrelated donors. Overall survival of the older donor group was significantly inferior to that of the younger donor group (adjusted hazard ratio 1.64; 95% confidence interval 1.15–2.35; P

Details

Language :
English
ISSN :
03906078, 15928721, and 76959287
Volume :
101
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Haematologica
Publication Type :
Academic Journal
Accession number :
edsdoj.3d7695928760410786cd30a4546828b9
Document Type :
article
Full Text :
https://doi.org/10.3324/haematol.2015.139469