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Allogeneic unrelated bone marrow transplantation from older donors results in worse prognosis in recipients with aplastic anemia
- Source :
- Haematologica, Vol 101, Iss 5 (2016)
- Publication Year :
- 2016
- Publisher :
- Ferrata Storti Foundation, 2016.
-
Abstract
- Allogeneic bone marrow transplantation is an essential therapy for acquired aplastic anemia and prognosis has recently improved. However, engraftment failure and graft-versus-host disease are potential fatal complications. Various risk factors for poor prognosis have been identified, such as patient age and human-leukocyte antigen disparity, but the relationship between donor age and prognosis is still unknown. Therefore, we performed a cohort study to compare the prognosis of unrelated bone marrow transplantation from younger and older donors using the registry database in Japan. We evaluated 427 patients (age 16–72 years) with aplastic anemia who underwent bone marrow transplantation from younger (≤39 years, n=281) or older (≥40 years, n=146) unrelated donors. Overall survival of the older donor group was significantly inferior to that of the younger donor group (adjusted hazard ratio 1.64; 95% confidence interval 1.15–2.35; P
- Subjects :
- Diseases of the blood and blood-forming organs
RC633-647.5
Subjects
Details
- Language :
- English
- ISSN :
- 03906078, 15928721, and 76959287
- Volume :
- 101
- Issue :
- 5
- Database :
- Directory of Open Access Journals
- Journal :
- Haematologica
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.3d7695928760410786cd30a4546828b9
- Document Type :
- article
- Full Text :
- https://doi.org/10.3324/haematol.2015.139469