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Beta-Blockers Show Inverse Agonism to a Novel Constitutively Active Mutant of β1-Adrenoceptor
- Source :
- Journal of Pharmacological Sciences, Vol 102, Iss 2, Pp 167-172 (2006)
- Publication Year :
- 2006
- Publisher :
- Elsevier, 2006.
-
Abstract
- We obtained a new mutant of the β1-adrenergic receptor (β1-AR) by point mutations that can constitutively activate β1-AR. Aspartate104 of the β1-AR in the 2nd transmembrane was replaced with alanine. The β1-AR mutant expressed in human embryonic kidney (HEK)-293 cells displayed high level of constitutive activity with respect to wild-type (P
- Subjects :
- Therapeutics. Pharmacology
RM1-950
Subjects
Details
- Language :
- English
- ISSN :
- 13478613
- Volume :
- 102
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Pharmacological Sciences
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.3d634c84f06347f5abb44f6077455725
- Document Type :
- article
- Full Text :
- https://doi.org/10.1254/jphs.FP0060640