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Clinical Characteristics of Sarcopenia in Nonalcoholic Fatty Liver Disease: A Systemic Scoping Review

Clinical Characteristics of Sarcopenia in Nonalcoholic Fatty Liver Disease: A Systemic Scoping Review

Authors :
Tingdan Ye
Ke Mi
Lin Zhu
Jonathan Li
Calvin Q. Pan
Source :
Obesity Facts, Pp 1-14 (2024)
Publication Year :
2024
Publisher :
Karger Publishers, 2024.

Abstract

Introduction: This systematic scoping review aimed to synthesize existing research findings on the clinical manifestations in patients with nonalcoholic fatty liver disease (NAFLD) and sarcopenia. Methods: Adhering to scoping review guidelines, we comprehensively searched five databases for literature on sarcopenia’s clinical manifestations in NAFLD patients from December 2013 to December 2023, meticulously compiling and synthesizing the findings. Results: A total of 312 articles were identified, with 9 studies included in the final review. Of these, 90% were cross-sectional investigations, with 70% from Asian cohorts. Comparative analysis between patients solely afflicted with NAFLD and those additionally experiencing sarcopenia revealed discernible trends. Individuals with both conditions tended to be older, have a higher body mass index, and show a higher prevalence among females, underscoring the influence of unhealthy lifestyles and obesity. Furthermore, comorbidities like metabolic syndrome, hypertension, and diabetes have been implicated in sarcopenia manifestation among NAFLD patients. Nonetheless, the lack of standardized diagnostic criteria and patterns poses an ongoing clinical challenge for this subgroup. Conclusions: Our review highlights distinct clinical characteristics evident in NAFLD patients with sarcopenia. However, comprehensive investigations remain scarce, impeding accurate early detection and intervention. Future research should prioritize bridging these gaps and fostering enhanced clinical management strategies.

Details

Language :
English
ISSN :
16624033
Database :
Directory of Open Access Journals
Journal :
Obesity Facts
Publication Type :
Academic Journal
Accession number :
edsdoj.3d5e8bf9834bcaa8ff7635b29fffbc
Document Type :
article
Full Text :
https://doi.org/10.1159/000541650