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Prognostic factors in phyllodes tumours of the breast: retrospective study on 166 consecutive cases
- Source :
- ESMO Open, Vol 5, Iss 5 (2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- Background Phyllodes tumours (PTs) are rare fibroepithelial tumours accounting for 5 cm vs T≤2 cm). Higher tumour-infiltrating lymphocytes (TILs) were associated with borderline and malignant PT (p=0.023); TILs were not associated with phyllodes-related relapse-free survival (HR 0.58, p=0.361 for TILs>2% vs≤2%). Overall, four patients died because of PT: three patients with malignant and one with borderline PT.Conclusions Patients with malignant PT had increased rates of phyllodes-related relapse and phyllodes-related death. Cellular atypia and heterologous differentiation were poor prognostic factors in the entire cohort; large tumour size was associated with an increased risk of phyllodes-related relapse in benign PT.
- Subjects :
- Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Subjects
Details
- Language :
- English
- ISSN :
- 20597029
- Volume :
- 5
- Issue :
- 5
- Database :
- Directory of Open Access Journals
- Journal :
- ESMO Open
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.3c7c72bd29746509cfeb4fa9974d264
- Document Type :
- article
- Full Text :
- https://doi.org/10.1136/esmoopen-2020-000843