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Molecular mechanisms of severe acute respiratory syndrome (SARS)

Authors :
Zabel Peter
Hilgenfeld Rolf
Groneberg David A
Source :
Respiratory Research, Vol 6, Iss 1, p 8 (2005)
Publication Year :
2005
Publisher :
BMC, 2005.

Abstract

Abstract Severe acute respiratory syndrome (SARS) is a new infectious disease caused by a novel coronavirus that leads to deleterious pulmonary pathological features. Due to its high morbidity and mortality and widespread occurrence, SARS has evolved as an important respiratory disease which may be encountered everywhere in the world. The virus was identified as the causative agent of SARS due to the efforts of a WHO-led laboratory network. The potential mutability of the SARS-CoV genome may lead to new SARS outbreaks and several regions of the viral genomes open reading frames have been identified which may contribute to the severe virulence of the virus. With regard to the pathogenesis of SARS, several mechanisms involving both direct effects on target cells and indirect effects via the immune system may exist. Vaccination would offer the most attractive approach to prevent new epidemics of SARS, but the development of vaccines is difficult due to missing data on the role of immune system-virus interactions and the potential mutability of the virus. Even in a situation of no new infections, SARS remains a major health hazard, as new epidemics may arise. Therefore, further experimental and clinical research is required to control the disease.

Details

Language :
English
ISSN :
14659921
Volume :
6
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Respiratory Research
Publication Type :
Academic Journal
Accession number :
edsdoj.3c6451552a09470aad59515004d32f06
Document Type :
article
Full Text :
https://doi.org/10.1186/1465-9921-6-8