Blocking the GITR-GITRL pathway to overcome resistance to therapy in sarcomatoid malignant pleural mesothelioma

Authors :: Meilin Chan
Licun Wu
Zhihong Yun
Trevor D. McKee
Michael Cabanero
Yidan Zhao
Mikihiro Kohno
Junichi Murakami
Marc de Perrot
Source :: Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Publication Year :: 2021
Publisher :: Nature Portfolio, 2021.
Abstract: Chan et al find that the GITR-GITRL pathway is an important mechanism of autocrine proliferation in sarcomatoid mesothelioma that could explain their resistance to therapy. Blocking the GITR-GITRL pathway could therefore be a new therapeutic target for non-epithelioid mesothelioma.

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