Back to Search Start Over

DEEP VEIN THROMBOSIS AND RECURENT PULMONARY EMBOLISM IN A PATIENT WITH THROMBOPHILIC MUTATIONS AND GENERALIZED PSORIASIS: A CASE REPORT

Authors :
Marjan Nove Baloski
Daniela Buklioska Ilievska
Vesna Brishkovska-Boshkovski
Taner Hasan
Natasa Nedeska Minova
Biljana Prgova-Veljanova
Andrea Nanceva Bogoevska
Jasminka Nanceva
Marijan Bosevski
Sasho Panov
Source :
Sanamed, Vol 15, Iss 2, Pp 183-188 (2020)
Publication Year :
2020
Publisher :
Association of medical doctors Sanamed Novi Pazar, 2020.

Abstract

Introduction: Genetic risk factors that increase venous thromboembolism risk are disorders in the synthesis or activity of coagulation factors. Factor V Leiden, prothrombin (20210-A), antithrombin deficiency, protein C and protein S deficiency, and hyperhomocysteinaemia are the most common venous thromboembolism-related gene mutations. When genetic factors are combined with non-provoking risk factors (obesity, psoriasis, smoking and previous venous thromboembolism) the result is increased venous thromboembolism risk for each factor individually. Previous venous thromboembolism is one of the strongest risk factors, even in patients actively treated with anticoagulant. Patients are more likely to have recurrent venous thromboembolism with longer duration. Psoriasis is a complex immune–mediated disease, associated with cardiovascular risk, hypercoagulability markers and elevated homocysteine. Lots of observational reports suggest increased incidence of venous trombembolic events in patient with psoriasis. Case presentation: We present patient with inherited thrombophilia and chronic diffuse plaque psoriasis complicated with deep venous thrombosis and pulmonary embolism. DNA analysis indicates the presence of homozygosis for Factor V Leiden mutation as well as heterozygosis for Factor XIII V34L, PAI -1 5G/4G and MTHFR A1298C polymorphism. Dermatological anamnesis is positive for plaque psoriasis since 12 years ago. Conclusion: The presentation of this case indicates an association between venous thromboembolism and chronic psoriasis. All patients with recurrent thromboembolism, hereditary thrombophilia, and moderate to severe psoriasis should be considered to be at higher risk for venous thromboembolism and appropriately treated.

Details

Language :
English
ISSN :
1452662X and 22178171
Volume :
15
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Sanamed
Publication Type :
Academic Journal
Accession number :
edsdoj.3c22c2cdee434f368c76ee76d751dc86
Document Type :
article
Full Text :
https://doi.org/10.24125/sanamed.v15i2.391