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Association of circadian rhythm disruption with metabolic diseases represented by obesity

Authors :
Wang Han
Source :
E3S Web of Conferences, Vol 553, p 05021 (2024)
Publication Year :
2024
Publisher :
EDP Sciences, 2024.

Abstract

The majority of creatures on Earth possess an intrinsic biological clock which situates in the suprachiasmatic nucleus of the hypothalamus. It produces a circadian rhythm that coincides with the Earth’s 24-hour cycle through a feedback loop that involves both transcription and translation, which means in regulating metabolism and energy homeostasis of various peripheral organs, such as liver, it plays an vital part. As a result, it has an intricate association in maintaining metabolic health. Outer environmental factors like lifestyle changes may cause Circadian rhythm disorders, and causing higher risk of obesity and metabolic diseases. Moreover, the intricate relationship between circadian rhythms and lipid metabolism is intricately linked to the progression of obesity. The disruption of these processes can significantly heighten the susceptibility to obesity through several mechanisms, therefore intensifying circadian abnormalities and establishing a detrimental cycle. This review will study the correlation between circadian rhythm and obesity, exploring many aspects such as process, influence and various factors.

Subjects

Subjects :
Environmental sciences
GE1-350

Details

Language :
English, French
ISSN :
22671242
Volume :
553
Database :
Directory of Open Access Journals
Journal :
E3S Web of Conferences
Publication Type :
Academic Journal
Accession number :
edsdoj.3c1585c833c743709d8975aa72a9c2a7
Document Type :
article
Full Text :
https://doi.org/10.1051/e3sconf/202455305021