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Improved Low-Glucose Predictive Alerts Based on Sustained Hypoglycemia: Model Development and Validation Study
- Source :
- JMIR Diabetes, Vol 6, Iss 2, p e26909 (2021)
- Publication Year :
- 2021
- Publisher :
- JMIR Publications, 2021.
-
Abstract
- BackgroundPredictive alerts for impending hypoglycemic events enable persons with type 1 diabetes to take preventive actions and avoid serious consequences. ObjectiveThis study aimed to develop a prediction model for hypoglycemic events with a low false alert rate, high sensitivity and specificity, and good generalizability to new patients and time periods. MethodsPerformance improvement by focusing on sustained hypoglycemic events, defined as glucose values less than 70 mg/dL for at least 15 minutes, was explored. Two different modeling approaches were considered: (1) a classification-based method to directly predict sustained hypoglycemic events, and (2) a regression-based prediction of glucose at multiple time points in the prediction horizon and subsequent inference of sustained hypoglycemia. To address the generalizability and robustness of the model, two different validation mechanisms were considered: (1) patient-based validation (model performance was evaluated on new patients), and (2) time-based validation (model performance was evaluated on new time periods). ResultsThis study utilized data from 110 patients over 30-90 days comprising 1.6 million continuous glucose monitoring values under normal living conditions. The model accurately predicted sustained events with >97% sensitivity and specificity for both 30- and 60-minute prediction horizons. The false alert rate was kept to
- Subjects :
- Diseases of the endocrine glands. Clinical endocrinology
RC648-665
Subjects
Details
- Language :
- English
- ISSN :
- 23714379
- Volume :
- 6
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- JMIR Diabetes
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.3c0e495d331545349f65021bf9fbfcf3
- Document Type :
- article
- Full Text :
- https://doi.org/10.2196/26909