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EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy
- Source :
- Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Portfolio, 2020.
-
Abstract
- Resistance to anti-HER2 therapies in breast cancer remains a significant clinical challenge. Here, the authors demonstrate that EZH2 regulates response to HER2-targeting therapies in breast cancer, in part, by modulating the expression of PPP2R2B.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 11
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.3c09063233a46f7b4d0dbd7cf8055f0
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-020-19704-x