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Understanding the Mechanism of Ferroptosis in Neurodegenerative Diseases

Authors :
Jiazi Ma
Jianwei Liu
Shangya Chen
Wanxin Zhang
Tian Wang
Mao Cao
Yong Yang
Yilun Du
Guanqun Cui
Zhongjun Du
Source :
Frontiers in Bioscience-Landmark, Vol 29, Iss 8, p 291 (2024)
Publication Year :
2024
Publisher :
IMR Press, 2024.

Abstract

Neurodegenerative disorders are typified by the progressive degeneration and subsequent apoptosis of neuronal cells. They encompass a spectrum of conditions, including Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), epilepsy, brian ischemia, brian injury, and neurodegeneration with brain iron accumulation (NBIA). Despite the considerable heterogeneity in their clinical presentation, pathophysiological underpinning and disease trajectory, a universal feature of these disorders is the functional deterioration of the nervous system concomitant with neuronal apoptosis. Ferroptosis is an iron (Fe)-dependent form of programmed cell death that has been implicated in the pathogenesis of these conditions. It is intricately associated with intracellular Fe metabolism and lipid homeostasis. The accumulation of Fe is observed in a variety of neurodegenerative diseases and has been linked to their etiology and progression, although its precise role in these pathologies has yet to be elucidated. This review aims to elucidate the characteristics and regulatory mechanisms of ferroptosis, its association with neurodegenerative diseases, and recent advances in ferroptosis-targeted therapeutic strategies. Ferroptosis may therefore be a critical area for future research into neurodegenerative diseases.

Details

Language :
English
ISSN :
27686701
Volume :
29
Issue :
8
Database :
Directory of Open Access Journals
Journal :
Frontiers in Bioscience-Landmark
Publication Type :
Academic Journal
Accession number :
edsdoj.3c045735d2cd4040b92702a219a5fe11
Document Type :
article
Full Text :
https://doi.org/10.31083/j.fbl2908291