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Synthesis and reducing power assay of methyl semicarbazone derivatives
- Source :
- Journal of Saudi Chemical Society, Vol 18, Iss 2, Pp 121-127 (2014)
- Publication Year :
- 2014
- Publisher :
- Elsevier, 2014.
-
Abstract
- In the present study we have designed a new pharmacophore ‘Chalconesemicarbazone’ by pharmacophore hybridization approach of drug design. A series of novel chalconesemicarbazones was synthesized and evaluated for their antioxidant activity by reducing power assay. Most of the compounds were found to be potent antioxidants. Free radicals play an important role in various pathological and xenotoxic effects so antioxidant may have protective role in these pathological conditions. Based on the results of reducing power assay 1-[1-(2,4-dihydroxyphenyl)-3-(2-hydroxyphenyl)allylidene]-4-(4-methylphenyl)semicarbazide (compound 18) and 1-[1-(2,5-dihydroxyphenyl)-3-(6-hydroxyphenyl)allylidene]-4-(4-methylphenyl)semicarbazide (compound 21) were the most active lead compounds. It was found that methoxy and hydroxyl substituted chalconesemicarbazones exhibited potent reducing power and unsubstituted compound showed less reducing potential.
- Subjects :
- Chalcones
Anti-oxidant
Semicarbazones
Reducing power
Chemistry
QD1-999
Subjects
Details
- Language :
- English
- ISSN :
- 13196103
- Volume :
- 18
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Saudi Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.3bced00e302945f48b04d39ec46f61e8
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.jscs.2011.06.004