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DIAPH1 mediates progression of atherosclerosis and regulates hepatic lipid metabolism in mice

Authors :
Laura Senatus
Lander Egaña-Gorroño
Raquel López-Díez
Sonia Bergaya
Juan Francisco Aranda
Jaume Amengual
Lakshmi Arivazhagan
Michaele B. Manigrasso
Gautham Yepuri
Ramesh Nimma
Kaamashri N. Mangar
Rollanda Bernadin
Boyan Zhou
Paul F. Gugger
Huilin Li
Richard A. Friedman
Neil D. Theise
Alexander Shekhtman
Edward A. Fisher
Ravichandran Ramasamy
Ann Marie Schmidt
Source :
Communications Biology, Vol 6, Iss 1, Pp 1-20 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

Male and female mice deficient in DIAPH1 are protected from the development of experimental atherosclerosis and display reduced cholesterol levels; these changes are linked to the regulation of SREBP1 subcellular localization.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
6
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.3b884c6d0ad746b0ae3401514cb0c693
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-023-04643-2