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PI‐RADS 3 score: A retrospective experience of clinically significant prostate cancer detection

Authors :
Andrés Camacho
Fatima Salah
Camden P. Bay
Jonathan Waring
Renato Umeton
Michelle S. Hirsch
Alexander P. Cole
Adam S. Kibel
Massimo Loda
Clare M. Tempany
Fiona M. Fennessy
Source :
BJUI Compass, Vol 4, Iss 4, Pp 473-481 (2023)
Publication Year :
2023
Publisher :
Wiley, 2023.

Abstract

Abstract Rationale and objectives The study aims to propose an optimal workflow in patients with a PI‐RADS 3 (PR‐3) assessment category (AC) through determining the timing and type of pathology interrogation used for the detection of clinically significant prostate cancer (csPCa) in these men based upon a 5‐year retrospective review in a large academic medical center. Materials and methods This United States Health Insurance Probability and Accountability Act (HIPAA)‐compliant, institutional review board‐approved retrospective study included men without prior csPCa diagnosis who received PR‐3 AC on magnetic resonance (MR) imaging (MRI). Subsequent incidence and time to csPCa diagnosis and number/type of prostate interventions was recorded. Categorical data were compared using Fisher's exact test and continuous data using ANOVA omnibus F‐test. Results Our cohort of 3238 men identified 332 who received PR‐3 as their highest AC on MRI, 240 (72.3%) of whom had pathology follow‐up within 5 years. csPCa was detected in 76/240 (32%) and non‐csPCa in 109/240 (45%) within 9.0 ± 10.6 months. Using a non‐targeted trans‐rectal ultrasound biopsy as the initial approach (n = 55), another diagnostic procedure was required to diagnose csPCa in 42/55 (76.4%) of men, compared with 3/21(14.3%) men with an initial MR targeted‐biopsy approach (n = 21); (p

Details

Language :
English
ISSN :
26884526
Volume :
4
Issue :
4
Database :
Directory of Open Access Journals
Journal :
BJUI Compass
Publication Type :
Academic Journal
Accession number :
edsdoj.3b8230abaeff42dfbb3c80fcff5d522a
Document Type :
article
Full Text :
https://doi.org/10.1002/bco2.231