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Alterations of gut microbiota in infants with biliary atresia identified by 16S rRNA-sequencing

Authors :
Fei Liu
Ru Wei
Xiaogang Xu
Menglong Lan
Boyuan Tao
Zijian Liang
Jixiao Zeng
Source :
BMC Pediatrics, Vol 24, Iss 1, Pp 1-8 (2024)
Publication Year :
2024
Publisher :
BMC, 2024.

Abstract

Abstract Background Biliary atresia (BA) is a severe neonatal disease with progressive intra- and extra-hepatic bile ducts inflammation and hepatic fibrosis. Characterization of gut microbiome profiles in infants with biliary atresia can provide valuable information and potential disease biomarkers. Our study aims to explore the relationship between gut microbiota and biliary atresia. Methods 16 S ribosomal RNA (rRNA) gene sequencing was carried out to identify the differences in composition and diversity of gut microbiota between infants with BA and healthy subjects. A total of 31 infants with biliary atresia and 20 healthy subjects were recruited. Results The composition of gut microbiota in BA group was significantly different with the normal control group (P

Details

Language :
English
ISSN :
14712431
Volume :
24
Issue :
1
Database :
Directory of Open Access Journals
Journal :
BMC Pediatrics
Publication Type :
Academic Journal
Accession number :
edsdoj.3b41f514e2a42bfb97b485ff39dce7d
Document Type :
article
Full Text :
https://doi.org/10.1186/s12887-024-04582-9