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Consensus guidelines for lumbar puncture in patients with neurological diseases

Authors :
Sebastiaan Engelborghs
Ellis Niemantsverdriet
Hanne Struyfs
Kaj Blennow
Raf Brouns
Manuel Comabella
Irena Dujmovic
Wiesje van derFlier
Lutz Frölich
Daniela Galimberti
Sharmilee Gnanapavan
Bernhard Hemmer
Erik Hoff
Jakub Hort
Ellen Iacobaeus
Martin Ingelsson
Frank Jan de Jong
Michael Jonsson
Michael Khalil
Jens Kuhle
Alberto Lleó
Alexandre deMendonça
José Luis Molinuevo
Guy Nagels
Claire Paquet
Lucilla Parnetti
Gerwin Roks
Pedro Rosa‐Neto
Philip Scheltens
Constance Skårsgard
Erik Stomrud
Hayrettin Tumani
Pieter Jelle Visser
Anders Wallin
Bengt Winblad
Henrik Zetterberg
Flora Duits
Charlotte E. Teunissen
Source :
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 8, Iss 1, Pp 111-126 (2017)
Publication Year :
2017
Publisher :
Wiley, 2017.

Abstract

Abstract Introduction Cerebrospinal fluid collection by lumbar puncture (LP) is performed in the diagnostic workup of several neurological brain diseases. Reluctance to perform the procedure is among others due to a lack of standards and guidelines to minimize the risk of complications, such as post‐LP headache or back pain. Methods We provide consensus guidelines for the LP procedure to minimize the risk of complications. The recommendations are based on (1) data from a large multicenter LP feasibility study (evidence level II‐2), (2) systematic literature review on LP needle characteristics and post‐LP complications (evidence level II‐2), (3) discussion of best practice within the Joint Programme Neurodegenerative Disease Research Biomarkers for Alzheimer's disease and Parkinson's Disease and Biomarkers for Multiple Sclerosis consortia (evidence level III). Results Our consensus guidelines address contraindications, as well as patient‐related and procedure‐related risk factors that can influence the development of post‐LP complications. Discussion When an LP is performed correctly, the procedure is well tolerated and accepted with a low complication rate.

Details

Language :
English
ISSN :
23528729
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Publication Type :
Academic Journal
Accession number :
edsdoj.3b2ab4ab4425bb35b616de021c18e
Document Type :
article
Full Text :
https://doi.org/10.1016/j.dadm.2017.04.007