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Imaging quality of an artificial intelligence denoising algorithm: validation in 68Ga PSMA-11 PET for patients with biochemical recurrence of prostate cancer

Authors :
Charles Margail
Charles Merlin
Tommy Billoux
Maxence Wallaert
Hosameldin Otman
Nicolas Sas
Ioana Molnar
Florent Guillemin
Louis Boyer
Laurent Guy
Marion Tempier
Sophie Levesque
Alban Revy
Florent Cachin
Marion Chanchou
Source :
EJNMMI Research, Vol 13, Iss 1, Pp 1-18 (2023)
Publication Year :
2023
Publisher :
SpringerOpen, 2023.

Abstract

Abstract Background 68 Ga-PSMA PET is the leading prostate cancer imaging technique, but the image quality remains noisy and could be further improved using an artificial intelligence-based denoising algorithm. To address this issue, we analyzed the overall quality of reprocessed images compared to standard reconstructions. We also analyzed the diagnostic performances of the different sequences and the impact of the algorithm on lesion intensity and background measures. Methods We retrospectively included 30 patients with biochemical recurrence of prostate cancer who had undergone 68 Ga-PSMA-11 PET-CT. We simulated images produced using only a quarter, half, three-quarters, or all of the acquired data material reprocessed using the SubtlePET® denoising algorithm. Three physicians with different levels of experience blindly analyzed every sequence and then used a 5-level Likert scale to assess the series. The binary criterion of lesion detectability was compared between series. We also compared lesion SUV, background uptake, and diagnostic performances of the series (sensitivity, specificity, accuracy). Results VPFX-derived series were classified differently but better than standard reconstructions (p 0.05). The SubtlePET® algorithm significantly decreased lesion SUV (p

Details

Language :
English
ISSN :
2191219X
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
EJNMMI Research
Publication Type :
Academic Journal
Accession number :
edsdoj.3aacc7212e7f451f9921fc483e968154
Document Type :
article
Full Text :
https://doi.org/10.1186/s13550-023-00999-y