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Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgenic SPAM mice

Authors :
Yuxing Xia
Stefan Prokop
Brach M. Bell
Kimberly-Marie M. Gorion
Cara L. Croft
Lith Nasif
Guilian Xu
Cara J. Riffe
Alyssa N. Manaois
Kevin H. Strang
Stephan S. Quintin
Giavanna Paterno
Malú Gámez Tansey
David R. Borchelt
Todd E. Golde
Benoit I. Giasson
Source :
Communications Biology, Vol 5, Iss 1, Pp 1-18 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

A mouse model with a predictable pathogenic tau protein progression is presented, enabling further investigation into tau pathology in neurodegenerative diseases.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
5
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.3a9421f02cdb4806af6f325540e97ae6
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-022-03373-1