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Formulation Development of Mirtazapine Liquisolid Compacts: Optimization Using Central Composite Design

Authors :
Faiza Naureen
Yasar Shah
Sayyed Ibrahim Shah
Muhammad Abbas
Inayat Ur Rehman
Salar Muhammad
Hamdullah Hamdullah
Khang Wen Goh
Fazli Khuda
Amjad Khan
Siok Yee Chan
Mehwish Mushtaq
Long Chiau Ming
Source :
Molecules, Vol 27, Iss 13, p 4005 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Mirtazapine is a tetracyclic anti-depressant with poor water solubility. The aim of this study was to improve the dissolution rate of mirtazapine by delivering the drug as a liquisolid compact. Central composite design (CCD) was employed for the preparation of mirtazapine liquisolid compacts. In this, the impacts of two independent factors, i.e., excipient ratio (carrier:coating) and different drug concentration on the response of liquisolid system were optimized. Liquisolid compacts were prepared using propylene glycol as a solvent, microcrystalline cellulose as a carrier, and silicon dioxide (Aerosil) as the coating material. The crystallinity of the formulated drug and the interactions between the excipients were examined using X-ray powder diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR), respectively. The dissolution study for the liquisolid compact was carried out as per FDA guidelines. The results showed loss of crystallinity of the mirtazapine in the formulation and was completely solubilized in non-volatile solvent and equally dispersed throughout the powder system. Moreover, drug dissolution was found to be higher in liquisolid compacts than the direct compressed conventional tablets (of mirtazapine). The liquisolid technique appears to be a promising approach for improving the dissolution of poorly soluble drugs like mirtazapine.

Details

Language :
English
ISSN :
14203049
Volume :
27
Issue :
13
Database :
Directory of Open Access Journals
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
edsdoj.3a795b5e54a40a5bba0cf36d16a3e5d
Document Type :
article
Full Text :
https://doi.org/10.3390/molecules27134005