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Pseudomonas aeruginosa sepsis presenting as oral ecthyma gangrenosum in identical twins with Bruton tyrosine kinase gene mutation: Two case reports and review of the literature

Authors :
Sheng-Chieh Lin
Bor-Luen Chiang
Yuarn-Jang Lee
Ya-Ting Chang
Shiuh-Bin Fang
Source :
Journal of Microbiology, Immunology and Infection, Vol 53, Iss 6, Pp 1030-1034 (2020)
Publication Year :
2020
Publisher :
Elsevier, 2020.

Abstract

X-linked agammaglobulinemia (XLA) is a primary immunodeficiency disease. We reported two 7-month-old identical male twins with Pseudomonas aeruginosa sepsis who initially manifested as oral ecthyma gangrenosum and were finally diagnosed to have XLA. In both cases, we confirmed the c.862C > T BTK missense mutation in exon 10 at the SH2 domain.

Details

Language :
English
ISSN :
16841182
Volume :
53
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Journal of Microbiology, Immunology and Infection
Publication Type :
Academic Journal
Accession number :
edsdoj.3a5cbbbf1b4d13bb88a8020aba6ead
Document Type :
article
Full Text :
https://doi.org/10.1016/j.jmii.2020.04.009