Back to Search Start Over

Albumin-Bilirubin Grade as a Novel Predictor of Survival in Advanced Extrahepatic Cholangiocarcinoma

Authors :
Yong Wang
Qing Pang
Hao Jin
Lei Zhou
Xiaosi Hu
Zhen Qian
Zhongran Man
Song Yang
Huichun Liu
Source :
Gastroenterology Research and Practice, Vol 2018 (2018)
Publication Year :
2018
Publisher :
Wiley, 2018.

Abstract

Aim. Child-Pugh (CP) grade has been used to assess liver function and postoperative outcomes in biliary tract neoplasms. The aim of this study was to preliminarily explore the prognostic significance of an alternative model of liver function, called albumin-bilirubin (ALBI) grade, in patients with extrahepatic cholangiocarcinoma (EHC). Methods. A total of 109 advanced EHC patients, who received percutaneous transhepatic biliary stenting combined with iodine-125 seed implantation from January 2012 to April 2017 in our department, were enrolled. Preoperative clinical data were collected to calculate the CP and ALBI grades. The performance of ALBI score in predicting postoperative death was compared with that of CP score by using the receiver operating characteristic (ROC) curve. Kaplan-Meier analysis and Cox regression model were performed for overall survival (OS) analysis. Results. The median survival time of our cohort was 12 months, and the 1-year and 2-year survival rates were 56.9% and 12.8%, respectively. The area under the ROC curve of ALBI score for predicting death was significantly greater than the CP score (0.751, 95% CI: 0.641–0.861, P

Details

Language :
English
ISSN :
16876121 and 1687630X
Volume :
2018
Database :
Directory of Open Access Journals
Journal :
Gastroenterology Research and Practice
Publication Type :
Academic Journal
Accession number :
edsdoj.3a57c8c009214ac8b369bf804aadeb88
Document Type :
article
Full Text :
https://doi.org/10.1155/2018/8902146