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Synthesized Phosphonium Compounds Demonstrate Resistant Modulatory and Antibiofilm Formation Activities against Some Pathogenic Bacteria

Authors :
Cedric Dzidzor Kodjo Amengor
Cynthia Amaning Danquah
Emmanuel Bentil Asare Adusei
Francis Klenam Kekessie
Francis Ofosu-Koranteng
Paul Peprah
Benjamin Kingsley Harley
Emmanuel Orman
Joseph Adu
Yussif Saaka
Source :
Heteroatom Chemistry, Vol 2022 (2022)
Publication Year :
2022
Publisher :
Hindawi-Wiley, 2022.

Abstract

A library of six compounds with new hybrids in a single molecule triazole ring attached to the phosphonium salts was synthesized. Click chemistry was, however, used to synthesize the 1-, 2-, and 3-triazole intermediates as a tether for the hybrid phosphonium salts. Their antibacterial activity against Gram-positive bacteria (Staphylococcus aureus and Enterococcus faecalis), Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), and Mycobacterium smegmatis mc2155 was determined using the HT-SPOTi assay. Compound 2 showed the most effective antimicrobial activity as it inhibited the growth of Pseudomonas aeruginosa and Staphylococcus aureus at 0.0125 µg/mL and 31.25 µg/mL, respectively. From the FICI data, compounds 2ET-TOL (2) and RABYL-TOL (4) successfully modulated the activities of amoxicillin against Pseudomonas aeruginosa and Staphylococcus aureus. All the test compounds exhibited a concentration-dependent biofilm formation inhibition against S. aureus, except P-Z (compound 6). Compounds P-MEOXY (1) and 2ET-TOL (2) exhibited mild activity against P. aeruginosa with compound 4 showing antimycobacterial activity at 500 µg/mL.

Details

Language :
English
ISSN :
10981071
Volume :
2022
Database :
Directory of Open Access Journals
Journal :
Heteroatom Chemistry
Publication Type :
Academic Journal
Accession number :
edsdoj.3a13e8d02654d62b042d9f2245e90a0
Document Type :
article
Full Text :
https://doi.org/10.1155/2022/7411957