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Synthesized Phosphonium Compounds Demonstrate Resistant Modulatory and Antibiofilm Formation Activities against Some Pathogenic Bacteria
- Source :
- Heteroatom Chemistry, Vol 2022 (2022)
- Publication Year :
- 2022
- Publisher :
- Hindawi-Wiley, 2022.
-
Abstract
- A library of six compounds with new hybrids in a single molecule triazole ring attached to the phosphonium salts was synthesized. Click chemistry was, however, used to synthesize the 1-, 2-, and 3-triazole intermediates as a tether for the hybrid phosphonium salts. Their antibacterial activity against Gram-positive bacteria (Staphylococcus aureus and Enterococcus faecalis), Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), and Mycobacterium smegmatis mc2155 was determined using the HT-SPOTi assay. Compound 2 showed the most effective antimicrobial activity as it inhibited the growth of Pseudomonas aeruginosa and Staphylococcus aureus at 0.0125 µg/mL and 31.25 µg/mL, respectively. From the FICI data, compounds 2ET-TOL (2) and RABYL-TOL (4) successfully modulated the activities of amoxicillin against Pseudomonas aeruginosa and Staphylococcus aureus. All the test compounds exhibited a concentration-dependent biofilm formation inhibition against S. aureus, except P-Z (compound 6). Compounds P-MEOXY (1) and 2ET-TOL (2) exhibited mild activity against P. aeruginosa with compound 4 showing antimycobacterial activity at 500 µg/mL.
- Subjects :
- Organic chemistry
QD241-441
Inorganic chemistry
QD146-197
Subjects
Details
- Language :
- English
- ISSN :
- 10981071
- Volume :
- 2022
- Database :
- Directory of Open Access Journals
- Journal :
- Heteroatom Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.3a13e8d02654d62b042d9f2245e90a0
- Document Type :
- article
- Full Text :
- https://doi.org/10.1155/2022/7411957