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Association of blood group a with colorectal cancer prevalence in Croatian population
- Source :
- Libri Oncologici, Vol 51, Iss 2-3, Pp 65-70 (2023)
- Publication Year :
- 2023
- Publisher :
- University Hospital for Tumors, 2023.
-
Abstract
- Purpose: The aim of our study was to investigate the association of ABO phenotypes and genotypes with colorectal cancer prevalence in Croatian population. Methods: Study included 80 patients (51 men) with colorectal cancer and 303 healthy volunteer blood donors (180 men) in the control group. Using the PCR-SSP method, genotyping was performed on 5 main alleles (O1, O2, A1, A2, B), resulting in 15 ABO genotypes. Results: There was no difference in the prevalence of colorectal cancer between men and women. There was no difference in a specific blood group phenotype between patients and healthy controls. However, there was a statistically significant higher odds ratio for individuals to carry blood group A than O in patients with colorectal cancer. There was no significant higher odds ratio for non-O genotypes compared to all genotypes constituting O blood group in patients with colorectal cancer. Conclusion: Our study has shown that there are higher odds for blood group A in colorectal patients than O when compared to healthy controls, suggesting blood group A could be a potential risk factor for colorectal cancer. This is accordant with some previously published studies. Further studies with larger group of patients and controls are needed to confirm this observation.
Details
- Language :
- English
- ISSN :
- 03008142 and 25843826
- Volume :
- 51
- Issue :
- 2-3
- Database :
- Directory of Open Access Journals
- Journal :
- Libri Oncologici
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.39f73cd94ab24c08993e0e5d2c06b24c
- Document Type :
- article
- Full Text :
- https://doi.org/10.20471/LO.2023.51.02-03.10