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Dinuclear Copper(I) Thiodiacetate Complex-Mediated Expeditious Synthesis of the Chlorine-Containing Cyclen-Cored 36-Glucose-Coated Glycodendrimer

Authors :
Anand K. Agrahari
Sunil Kumar
Anindra Sharma
Vinod K. Tiwari
Source :
Journal of Chemistry, Vol 2021 (2021)
Publication Year :
2021
Publisher :
Wiley, 2021.

Abstract

High-sugar-tethered glycodendrimers are a remarkable tool in glycobiology for the investigation of carbohydrate-protein interaction using its multivalency property. An enthralling double-stage convergent synthetic approach was selected to build a novel class of chlorine-containing glucose-coated dendrimers using an efficient click catalyst ‘dinuclear copper(I) thiodiacetate complex.’ In this context, cyclen core was developed through a divergent approach, while the glucodendron was developed via a convergent approach independently. Both azide-alkyne partners were coupled through a modular copper azide-alkyne cycloaddition (CuAAC) strategy to afford a high yield of the desired 36-glucose-coated glycodendrimer. The synthesized glycodendrimer has been elucidated by NMR, gel permeation chromatography (GPC), and IR spectral analysis.

Subjects

Subjects :
Chemistry
QD1-999

Details

Language :
English
ISSN :
20909071
Volume :
2021
Database :
Directory of Open Access Journals
Journal :
Journal of Chemistry
Publication Type :
Academic Journal
Accession number :
edsdoj.39431bf03af4471a81043979258e6334
Document Type :
article
Full Text :
https://doi.org/10.1155/2021/4209514