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Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk

Authors :
Kira A. Perzel Mandell
Nicholas J. Eagles
Richard Wilton
Amanda J. Price
Stephen A. Semick
Leonardo Collado-Torres
William S. Ulrich
Ran Tao
Shizhong Han
Alexander S. Szalay
Thomas M. Hyde
Joel E. Kleinman
Daniel R. Weinberger
Andrew E. Jaffe
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

The authors provide a comprehensive, single base resolution view of association between genetic variation and DNA methylation in human brain. They also show that heritability attributed to schizophrenia GWAS-associated variants reflects the epigenetic plasticity of the brain.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723 and 39209296
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.39209296bd643a888732cfc9a82670a
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-25517-3