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An antibody against L1 cell adhesion molecule inhibits cardiotoxicity by regulating persistent DNA damage
- Source :
- Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- Mechanisms underlying the cardiotoxicity associated with thoracic irradiation and doxorubicin treatment during anticancer therapy remain poorly understood. Here the authors show that treatment with an antibody against the L1 cell adhesion molecule inhibits nuclear L1CAM translocation, thereby controlling vascular DNA damage and preventing cardiotoxicity.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 12
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.390ba1c3b7ef40a4a2315adde73d9f10
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-021-23478-1