Antibacterial Antibiotics and Bacterial Probiotics: is it Possible to Combine the Incompatible

The purpose of the study was to analyze validity and effectiveness of simultaneous application of bacterial probiotics and antibacterial antibiotics during antimicrobial therapy. Materials and methods. The review includes materials of foreign and domestic researchers published in modern periodical and monographic literature. Results. The conceptual material of the main terms and definitions of «ideal» antibiotics and probiotics is presented. The dominant role of bacterial probiotics in the group of medical probiotics in the Russian pharmaceutical market was established. A comparative assessment of the data on the passportization, identification, and sensitivity to antibiotics of a number of commercial probiotic cultures was carried out. The article considers theoretical and practical joint use of antibiotics, probiotics, and metabiotics during antimicrobial therapy. Conclusion. The current practice ofjoint use of probiotics and antibiotics in the process of antimicrobial therapy is extremely limited and indicates the presence of serious circumstances that reduce the effectiveness of probiotic therapy. One of the directions that exclude this situation is the use of metabiotics in the form of medications.