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Astrocytic chloride is brain state dependent and modulates inhibitory neurotransmission in mice
- Source :
- Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
- Publication Year :
- 2023
- Publisher :
- Nature Portfolio, 2023.
-
Abstract
- Astrocytes act as a dynamic Cl− reservoir regulating Cl− homeostasis in the CNS. Astrocytic Cl− is high and stable during sleep, it is lower during wakefulness and fluctuates in response to sensory input and motor activity. Efflux of Cl− from astrocytes supports inhibitory transmission in the CNS.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 14
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.38d2da81b87c466da2c47d8b24e79713
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-023-37433-9