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Human-T-Cell-Selective Fluorescent Probe
- Source :
- Cells, Vol 11, Iss 18, p 2836 (2022)
- Publication Year :
- 2022
- Publisher :
- MDPI AG, 2022.
-
Abstract
- The identification of T and B lymphocytes has relied on using antibodies against different biomarkers as the gold standard. Emerging small molecule-based fluorescent probes have the potential to replace antibodies. Herein, we report the first human-T-cell-selective fluorescent probe, Mito thermo yellow (MTY), achieving the live T cells’ distinction from B cells, which was previously impossible without the help of antibodies. The unexpected cell selectivity of MTY is attributed to the higher mitochondria mass and membrane potential of T cells over B cells. This study enriches the toolbox for live cell distinction from complex cell communities.
Details
- Language :
- English
- ISSN :
- 20734409
- Volume :
- 11
- Issue :
- 18
- Database :
- Directory of Open Access Journals
- Journal :
- Cells
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.38aa328586a54341b26d0b2901ebd427
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/cells11182836