Correlation between tubulointerstitial lesion and blood pressure in lupus nephritis patients a pathological, retrospective study

Objective: To study the influence of pathological factors of glomerular, tubulointerstitial, and arteriosclerotic lesions on the blood pressure of lupus nephritis. Methods: The pathological data and clinical characteristics of 69 lupus nephritis patients who underwent their first renal biopsy in Chengdu Second People’s Hospital from 2012 to 2018 were retrospectively analyzed. The revised 2018 ISN/RPS classification criteria of lupus nephritis were used to assess the glomerular and tubulointerstitial lesions. The lesion index of interlobar/arcuate artery and arteriolar was calculated. Multiple linear regressions were used to analyze the effects of glomerular lesion (GL), tubulointerstitial lesion (TIL), and vascular lesion (VL) on estimated glomerular filtration rate (eGFR), systolic blood pressure, and proteinuria. Results: TIL and VL scores were different between the various grades of blood pressure (p = 0.009, 0.019). After adjusting for gender and age, multiple linear regression showed that only TIL was linearly correlated with systolic blood pressure (p = 0.022). Conclusion: After adjusting for gender and age, TIL is related to systolic blood pressure, and has a linear relationship with them.