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HLA-DR Mismatch and Black Race Are Associated With Recurrent Autoimmune Hepatitis After Liver Transplantation
- Source :
- Transplantation Direct, Vol 7, Iss 7, p e714 (2021)
- Publication Year :
- 2021
- Publisher :
- Wolters Kluwer, 2021.
-
Abstract
- Background. The predictors of recurrent autoimmune hepatitis (R-AIH) after liver transplantation (LT) are heterogeneous with limited data to guide immunosuppression, with little data on impact of race. Aims. To describe the incidence, predictors, and outcomes of R-AIH. Methods. We studied patients undergoing LT for AIH during 2000–2017 at our center. Liver biopsies were performed for clinical indications. R-AIH was defined using clinical and histologic criteria. Results. Among 75 patients undergoing LT for AIH (mean age 45 ± 16, 65% female individuals, 19% Black), 71 (95%) received antithymocyte globulin induction with tacrolimus-based immunosuppression. R-AIH developed in 20 (27%) patients at a median interval of 313 d (interquartile range, 155–1205). R-AIH was associated with level 2 HLA-DR mismatch (hazard ratio, 3.6; (95% confidence interval, 1.3-9.9; P = 0.01) and Black race (hazard ratio, 4.5; 95% confidence interval, 1.8-11.8; P = 0.002)] in the multivariable analysis. R-AIH developed in 62% of patients with level 2 HLA-DR mismatch on single-agent immunosuppression but in
Details
- Language :
- English
- ISSN :
- 23738731 and 00000000
- Volume :
- 7
- Issue :
- 7
- Database :
- Directory of Open Access Journals
- Journal :
- Transplantation Direct
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.38498a85447580574eda7317ec47
- Document Type :
- article
- Full Text :
- https://doi.org/10.1097/TXD.0000000000001160