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Structure- and computational-aided engineering of an oxidase to produce isoeugenol from a lignin-derived compound

Authors :
Yiming Guo
Laura Alvigini
Milos Trajkovic
Lur Alonso-Cotchico
Emanuele Monza
Simone Savino
Ivana Marić
Andrea Mattevi
Marco W. Fraaije
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Lignin can be depolymerized into 4-alkylphenols by chemical means. Here the authors show a three-step computational-assisted enzyme engineering process to generate a biocatalyst for the conversion of lignin-derived 4-n-propylguaiacol into isoeugenol, a valuable compound.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.37ff37b3291449808fa6ca0f2f381cfb
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-34912-3