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Dynamic changes in clinical biomarkers of cardiometabolic diseases by changes in exercise behavior, and network comparisons: a community-based prospective cohort study in Korea

Authors :
JooYong Park
Jaesung Choi
Ji-Eun Kim
Sang-Min Park
Joo-Youn Cho
Daehee Kang
Miyoung Lee
Ji-Yeob Choi
Source :
Epidemiology and Health, Vol 45 (2023)
Publication Year :
2023
Publisher :
Korean Society of Epidemiology, 2023.

Abstract

OBJECTIVES Lifestyles, including exercise behaviors, change continually over time. This study examined whether the clinical biomarkers (CBs) related to cardiometabolic diseases (CMDs) and their relationships differed with changes in exercise behavior. METHODS The Ansan-Ansung cohort study (third to fifth phases; n=2,668) was used in the current study. Regular exercise behavior was investigated using a yes/no questionnaire. Changes in exercise behavior were classified into 4 groups: Y-N, N-Y, Y-Y, and N-N, with ā€œYā€ indicating that a participant regularly engaged in exercise at a given time point and ā€œNā€ indicating that he or she did not. Fourteen CBs related to CMDs were used, and the associations between changes in exercise behavior and relative changes in CBs were examined. CB networks were constructed and topological comparisons were conducted. RESULTS Y-N was associated with increases in fasting blood sugar and insulin levels in men, and increased total cholesterol and low-density lipoprotein cholesterol levels in women. Meanwhile, N-Y was inversely associated with body fat percentage, visceral fat percentage, fasting insulin, and triglyceride level. Waist circumference played a central role in most networks. In men, more edges were found in the N-Y and Y-Y groups than in the N-N and Y-N groups, whereas women in the N-Y and Y-Y groups had more edges than those in the N-N and Y-N groups. CONCLUSIONS Consistent exercise or starting to engage in regular exercise had favorable effects on CBs related to CMDs, although their network patterns differed between the sexes.

Details

Language :
English
ISSN :
20927193
Volume :
45
Database :
Directory of Open Access Journals
Journal :
Epidemiology and Health
Publication Type :
Academic Journal
Accession number :
edsdoj.37f6a25e2a094a8c924aad60cd1d4c43
Document Type :
article
Full Text :
https://doi.org/10.4178/epih.e2023026