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ASSOCIATION OF CAROTID INTIMA-MEDIA THICKNESS WITH LEPTIN AND APOLIPOPROTEIN B/APOLIPOPROTEIN A-I RATIO REVEALS IMMINENT PREDICTORS OF SUBCLINICAL ATHEROSCLEROSIS IN PSORIASIS PATIENTS
- Source :
- Acta Medica, Vol 57, Iss 1, Pp 21-27 (2014)
- Publication Year :
- 2014
- Publisher :
- Karolinum Press, 2014.
-
Abstract
- Psoriasis patients are often susceptible to cardiovascular diseases (CVD), including atherosclerosis. Traditional markers (biochemical and inflammatory) and diagnostic tools could detect occlusive but not subclinical atherosclerosis. Carotid intima-media thickness (CIMT), has recently been recognised as a non invasive diagnostic tool for identification of premature atherosclerosis. Therefore we evaluated 80 psoriasis patients and 80 age sex matched healthy controls for serum leptin levels and apolipoprotein B/apolipoprotein A-I ratio (apoB/apoA-I ratio) in relation with CIMT of carotid artery. Carotid intima-media thickness and carotid plaques were simultaneously measured by carotid sonography. Serum concentration of leptin and apolipoprotein were measured using enzyme-linked immuno sorbent assay (ELISA) and nephelometry respectively. Raised CIMT correlated to age of onset of the disease, serum leptin and apoB/apoA-I ratio in psoriasis patients. Taking into account, values that were above the 75 percentile of the three markers (leptin, apoB/apoA-I ratio and CIMT) the odds ratio was 4.26 (2.06–8.80 CI). Leptin and apoB/apoA-I ratio showed significant cumulative association with CIMT. Results of predictive analysis supports measurement of CIMT along with estimation of serum leptin and apoB/apoA-I ratio for prediction of premature atherosclerosis in psoriasis patients.
- Subjects :
- Apolipoprotein
apoB/apoA-I
Leptin
Psoriasis
CIMT
Atherosclerosis
Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 18059694 and 12114286
- Volume :
- 57
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Acta Medica
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.37f4cd5213504ed28e2d913b2660f3b7
- Document Type :
- article
- Full Text :
- https://doi.org/10.14712/18059694.2014.4