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Cancer metabolites: promising biomarkers for cancer liquid biopsy

Authors :
Wenxiang Wang
Zhiwei Rong
Guangxi Wang
Yan Hou
Fan Yang
Mantang Qiu
Source :
Biomarker Research, Vol 11, Iss 1, Pp 1-14 (2023)
Publication Year :
2023
Publisher :
BMC, 2023.

Abstract

Abstract Cancer exerts a multitude of effects on metabolism, including the reprogramming of cellular metabolic pathways and alterations in metabolites that facilitate inappropriate proliferation of cancer cells and adaptation to the tumor microenvironment. There is a growing body of evidence suggesting that aberrant metabolites play pivotal roles in tumorigenesis and metastasis, and have the potential to serve as biomarkers for personalized cancer therapy. Importantly, high-throughput metabolomics detection techniques and machine learning approaches offer tremendous potential for clinical oncology by enabling the identification of cancer-specific metabolites. Emerging research indicates that circulating metabolites have great promise as noninvasive biomarkers for cancer detection. Therefore, this review summarizes reported abnormal cancer-related metabolites in the last decade and highlights the application of metabolomics in liquid biopsy, including detection specimens, technologies, methods, and challenges. The review provides insights into cancer metabolites as a promising tool for clinical applications.

Details

Language :
English
ISSN :
20507771
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Biomarker Research
Publication Type :
Academic Journal
Accession number :
edsdoj.376c95befd1e48689672febf70f012c2
Document Type :
article
Full Text :
https://doi.org/10.1186/s40364-023-00507-3