Back to Search
Start Over
Characterizing the loss and acquisition of Tn2-like transposon in Klebsiella pneumoniae: Implications for carbapenemase gene dissemination
- Source :
- Journal of Global Antimicrobial Resistance, Vol 38, Iss , Pp 98-102 (2024)
- Publication Year :
- 2024
- Publisher :
- Elsevier, 2024.
-
Abstract
- ABSTRACT: Over 1 year, two KPC-producing and two non–KPC-producing Klebsiella pneumoniae strains were isolated from a patient. Genome and DNA hybridization analyses revealed the first three strains as a clonal lineage, with carbapenem resistance changes due to a Tn2-like transposon on an IncR/IncFII plasmid. The fourth strain, carrying three plasmids, caused a lethal infection and represented a different lineage. All strains belonged to the ST11-SL47-OL101 type. This study highlights the Tn2-like transposon's role in carbapenemase gene spread and the importance of distinguishing between bacterial colonization and infection.
- Subjects :
- Klebsiella pneumoniae
Plasmid
Transposon
KPC-2
Microbiology
QR1-502
Subjects
Details
- Language :
- English
- ISSN :
- 22137165
- Volume :
- 38
- Issue :
- 98-102
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Global Antimicrobial Resistance
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.372aad52b1e54a519af56dc934463201
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.jgar.2024.04.011