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New pro-inflammatory cytokine IL-40 is produced by activated neutrophils and plays a role in the early stages of seropositive rheumatoid arthritis
- Source :
- RMD Open, Vol 9, Iss 2 (2023)
- Publication Year :
- 2023
- Publisher :
- BMJ Publishing Group, 2023.
-
Abstract
- Objective Interleukin (IL)-40 is a new cytokine related to immune system function and malignancies. Recently, an association of IL-40 with rheumatoid arthritis (RA) and externalisation of neutrophil extracellular traps (NETosis) was found. As neutrophils are implicated in RA development, we investigated IL-40 in early stages of RA (ERA).Methods IL-40 was determined in serum of treatment naïve patients with ERA at baseline (n=60) and 3 months after initiation of conventional therapy and in healthy controls (HC; n=60). Levels of IL-40, cytokines and NETosis markers were measured by ELISA. NETosis was visualised by immunofluorescence. In vitro experiments were performed on peripheral blood neutrophils from ERA patients (n=14). Cell-free DNA was analysed in serum and supernatants.Results Serum IL-40 was elevated in ERA compared with HC (p
- Subjects :
- Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 20565933
- Volume :
- 9
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- RMD Open
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.372a0b12cd9b42f2a35fc7052e971e4a
- Document Type :
- article
- Full Text :
- https://doi.org/10.1136/rmdopen-2022-002894